SDKP Downloads

Sleep and circadian associations

Dataset name in SDKP Publication Phenotypes Download
UK Biobank Sleep Traits GWAS: Self-report Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Wang H, et al.
, Nat Commun. 2019 Aug 13;10(1):3503. doi: 10.1038/s41467-019-11456-7. PMID:31409809 Sleep and Circadian Daytime sleepiness associations | README
Daytime sleepiness adj BMI associations | README
UK Biobank Sleep GWAS: Accelerometer-derived Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Jones, S.E., et al.
, Nat Commun. 2019 Apr 5;10(1):1585. doi: 10.1038/s41467-019-09576-1. PMID:30952852 Sleep and Circadian Download file | README
Sleeping oxyhemoglobin saturation GWAS Associations of Variants In the Hexokinase 1 and Interleukin 18 Receptor Regions with Oxyhemoglobin Saturation During Sleep. Cade, B.E., et al.
, PLoS Genet. 2019 Apr 16;15(4):e1007739. doi: 10.1371/journal.pgen.1007739. PMID:30990817 Sleep and Circadian Average SpO2 associations | Minimum SpO2 associations | Percentage of sleep with SpO2 < 90% associations | README
UK Biobank Sleep Traits GWAS: Self-report (insomnia associations) Biological and clinical insights from genetics of insomnia symptoms. Lane, J., et al.
, Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. PMID:30804566 Sleep and Circadian Insomnia associations | 
README
UK Biobank Sleep Traits GWAS: Self-report (chronotype associations) Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Jones, S.E., et al.
, Nat Commun. 2019 Jan 29;10(1):343. doi: 10.1038/s41467-018-08259-7. PMID:30696823 Sleep and Circadian

Chronotype (morningness) associations | README

Morning person (binary chronotype) associations | README

UK Biobank Sleep Traits GWAS: Self-report (sleep duration associations) Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Dashti, H.S., et al.
, Nat Commun. 2019 Mar 7;10(1):1100. doi: 10.1038/s41467-019-08917-4. PMID:30846698 Sleep and Circadian

Overall sleep duration associations | README

Long sleep duration associations | README

Short sleep duration associations | README

Obstructive sleep apnea GWAS Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Chen H, et al., Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401. doi: 10.1165/rcmb.2017-0237OC. PMID:29077507 Sleep and Circadian AHI - all associations
AHI - females
AHI - males
AHI - European Americans
AHI - European Americans, females
AHI - European Americans, males
AHI in NREM sleep - all associations
AHI in NREM sleep - females
AHI in NREM sleep - males
AHI in NREM sleep - European Americans
AHI in NREM sleep - European Americans, females
AHI in NREM sleep - European Americans, males
AHI in REM sleep - all associations
AHI in REM sleep - females
AHI in REM sleep - males
AHI in REM sleep - European Americans
AHI in REM sleep - European Americans, females
AHI in REM sleep - European Americans, males
EAGLE child sleep duration GWAS Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium. Marinelli M, et al.
, Sleep. 2016 Oct 1; 39(10): 1859–1869. doi: 10.5665/sleep.6170. PMID:27568811 Sleep and Circadian Download files

Other associations

Dataset name in SDKP Publication Phenotypes Download site
GIANT UK Biobank GWAS Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Yengo, L., et al., Hum Mol Genet. 2018 Aug 16. doi: 10.1093/hmg/ddy271. PMID:30124842 Anthropometric Download site
DIAGRAM 1000G GWAS An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Scott, R.A., et al.
, Diabetes. 2017 Nov;66(11):2888-2902. doi: 10.2337/db16-1253. PMID:28566273 Glycemic Download site
MAGIC HbA1c GWAS (all ancestries) 



Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Wheeler, E., et al.
, PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383. PMID:28898252 Glycemic Download site
CKDGen 1000G GWAS 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Gorski, M., et al.
, Sci Rep. 2017 Apr 28;7:45040. doi: 10.1038/srep45040. PMID:28452372 Renal Download site
GIANT GWAS - stratified by physical activity Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Graff, M., et al., PLoS Genet. 2017 Apr 27;13(4):e1006528. doi: 10.1371/journal.pgen.1006528. PMID:28448500 Anthropometric Download site
MAGIC GWAS 

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Walford, G.A., Gustafsson, S., Rybin, D., et al.
, Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. PMID:27416945 Glycemic Download site
gnomAD exomes Analysis of protein-coding genetic variation in 60,706 humans. Lek, M., et al., Nature. 2016 Aug 18;536(7616):285-91. doi: 10.1038/nature19057. PMID:27535533 No phenotype Download site
gnomAD whole genomes Analysis of protein-coding genetic variation in 60,706 humans. Lek, M., et al., Nature. 2016 Aug 18;536(7616):285-91. doi: 10.1038/nature19057. PMID:27535533 No phenotype Download site
CKDGen 1000G GWAS - stratified UACR associations Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes. Teumer, A., et al.
, Diabetes. 2016 Mar;65(3):803-17. doi: 10.2337/db15-1313. PMID:26631737 Renal Download site
Leptin GWAS Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Kilpeläinen, T.O., et al.
, Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494. PMID:26833098 Glycemic Download site
Body Fat Percentage GWAS New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu, Y., et al.
, Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495. PMID:26833246 Anthropometric Download site
DIAGRAM Trans-ethnic meta-analysis Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Gaulton, K.J., et al.
, Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. PMID:26551672 Glycemic Download site
CARDIoGRAMplusC4D GWAS A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nikpay, M., et al.
, Nat Genet. 2015 Oct;47(10):1121-30. doi: 10.1038/ng.3396. PMID:26343387 Cardiovascular Download site
1000 Genomes A global reference for human genetic variation. 1000 Genomes Project Consortium, et al.
, Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393. PMID:26432245 No phenotype Download site
GIANT Anthropometric 2015 Waist GWAS New genetic loci link adipose and insulin biology to body fat distribution. Shungin, D., et al., Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132. PMID:25673412 Anthropometric Download site
GLGC GWAS Discovery and refinement of loci associated with lipid levels. Willer, C.J., et al., Nat Genet. 2013 Nov;45(11):1274-83. doi: 10.1038/ng.2797. PMID:24097068 Lipids Download site
Heart Rate GWAS Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed, M., et al., Nat Genet. 2013 Jun;45(6):621-31. doi: 10.1038/ng.2610. PMID:23583979 Cardiovascular Download site
Global Urate Genetics Consortium GWAS Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Köttgen, A., et al., Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. PMID:23263486 Metabolite Download site
GIANT GWAS FTO genotype is associated with phenotypic variability of body mass index. Yang, J., et al., Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401. PMID:22982992 Anthropometric Download site
MAGIC Metabochip GWAS 



Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Scott, R.A., et al.
, Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385. PMID:22885924 Glycemic Download site
ADIPOGen GWAS Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani, Z., et al.
, PLoS Genet. 2012;8(3):e1002607. doi: 10.1371/journal.pgen.1002607. PMID:22479202 Glycemic Download site
Early Growth Genetics Consortium GWAS A genome-wide association meta-analysis identifies new childhood obesity loci. Bradfield, J.P., et al.
, Nat Genet. 2012 May;44(5):526-31. doi: 10.1038/ng.2247. PMID:22484627 Anthropometric Download site