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Download GWAS summary statistics from studies on stroke and related traits

        
        
        

Download GWAS summary statistics from studies incorporated into the CDKP


GWAS summary statistics from studies on stroke and related traits

Datasets listed in this table are not integrated into the CDKP. The table is ordered by publication date in reverse chronological order.

 

Publication Download files README file
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.
Persyn E, et al.
Nat Commun. 2020 May 1;11(1):2175. doi: 10.1038/s41467-020-15932-3.
PMID:32358547

Download GWAS_UKB_PC1_FA.zip

Download GWAS_UKB_PC1_MD.zip

Download GWAS_UKB_logWMHnorm.zip

README
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Malik R, et al.
Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3.
PMID:29531354
Download available here  
Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.
Lubitz SA, et al.
Stroke. 2017 Jun;48(6):1451-1456. doi: 10.1161/STROKEAHA.116.016198.
PMID:28468926
Information for download  
Genetic variation at 16q24.2 is associated with small vessel stroke
Traylor M, et al.
Ann Neurol. 2017 Mar;81(3):383-394. doi: 10.1002/ana.24840.
PMID:27997041
27997041.Traylor.2017.tar.gz (299MB) README
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.
Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC).
Lancet Neurol. 2016 Jun;15(7):695-707. doi: 10.1016/S1474-4422(16)00102-2.
PMID:27068588
Information for download  
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.
Malik R, et al.
Neurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528.
PMID:26935894
4818561.Malik.2016.zip (1.3GB) README
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Traylor M, et al.

Neurology. 2016 Jan 12;86(2):146-53. doi: 10.1212/WNL.0000000000002263.
PMID:26674333
26674333.Traylor.2016.txt.gz (101MB) README
Multi-ethnic genome-wide association study of cerebral white matter hyperintensities on MRI.
Verhaaren BF, et al.
Circ Cardiovasc Genet. 2015 Apr;8(2):398-409. doi: 10.1161/CIRCGENETICS.114.000858.
PMID:25663218
Information for download  
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Kilarski LL, et al.
Neurology. 2014 Aug 19;83(8):678-85. doi: 10.1212/WNL.0000000000000707.
PMID:25031287
Information for download  
A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Traylor M, et al.
PLoS Genet. 2014 Jul 31;10(7):e1004469. doi: 10.1371/journal.pgen.1004469.
PMID:25078452
Information for download  
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Traylor M, et al.
Lancet Neurol. 2012 Nov;11(11):951-62. doi: 10.1016/S1474-4422(12)70234-X.
PMID:23041239
3490334.Traylor.2012.zip (307MB) README
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
Holliday EG, et al.
Nat Genet. 2012 Oct;44(10):1147-51. doi: 10.1038/ng.2397.
PMID:22941190
Information for download  
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
International Stroke Genetics Consortium, et al.
Nat Genet. 2012 Feb 5;44(3):328-33. doi: 10.1038/ng.1081.
PMID:22306652
Information for download  
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.
Fornage M, et al.
Ann Neurol. 2011 Jun;69(6):928-39. doi: 10.1002/ana.22403.
PMID:21681796
Information for download
(More information at the CHARGE Consortium website)
 

GWAS summary statistics from studies incorporated into the CDKP

The table is ordered by publication date in reverse chronological order.

 

Dataset name in CDKP Publication Phenotypes Download links
Intracranial aneurysm GWAS Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
Bakker MK, et al.
Nat Genet. 2020 doi: 10.1038/s41588-020-00725-7
Aneurysm

Download summary statistics

README

Cerebral Small Vessel Disease Multi-Trait Analysis of GWAS Genome-wide association study of cerebral small vessel disease reveals established and novel loci.
Chung J, et al.
Brain. 2019 Oct 1;142(10):3176-3189. doi: 10.1093/brain/awz233.
PMID:31430377
Stroke

Intracerebral hemorrhage or small vessel ischemic stroke summary statistics

Lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics

Non-lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics

README

GISCOME ischemic stroke outcome GWAS Genome-wide Association Meta-Analysis of Functional Outcome After Ischemic Stroke.
Söderholm M, et al.
Neurology. 2019 Mar 19;92(12):e1271-e1283. doi: 10.1212/WNL.0000000000007138.
PMID:30796134
Ischemic stroke outcome

mRS 0-1 vs 2-6 at 3 months

mRS 0-1 vs 2-6 at 3 months adj stroke severity

mRS 0-2 vs 3-6 at 3 months

mRS 0-2 vs 3-6 at 3 months adj stroke severity

mRS at 3 months

mRS at 3 months adj stroke severity

README

Cerebral WMHV GWAS 2019 Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).
Traylor M, et al.

Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952.
PMID:30659137
MRI Traits Summary statistics | README
ICH GWAS Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.
Woo D, et al.
Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012.
PMID:24656865
Hemorrhagic stroke Summary statistics (350MB) | README