Download GWAS summary statistics from studies on stroke and related traits |
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Download GWAS summary statistics from studies incorporated into the CDKP |
GWAS summary statistics from studies on stroke and related traits
Datasets listed in this table are not integrated into the CDKP. The table is ordered by publication date in reverse chronological order.
| Publication | Download files | README file |
|---|---|---|
| Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants. Persyn E, et al. Nat Commun. 2020 May 1;11(1):2175. doi: 10.1038/s41467-020-15932-3. PMID:32358547 |
README | |
| Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Malik R, et al. Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. PMID:29531354 |
Download available here | |
| Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Lubitz SA, et al. Stroke. 2017 Jun;48(6):1451-1456. doi: 10.1161/STROKEAHA.116.016198. PMID:28468926 |
Information for download | |
| Genetic variation at 16q24.2 is associated with small vessel stroke Traylor M, et al. Ann Neurol. 2017 Mar;81(3):383-394. doi: 10.1002/ana.24840. PMID:27997041 |
27997041.Traylor.2017.tar.gz (299MB) | README |
| Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC). Lancet Neurol. 2016 Jun;15(7):695-707. doi: 10.1016/S1474-4422(16)00102-2. PMID:27068588 |
Information for download | |
| Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Malik R, et al. Neurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528. PMID:26935894 |
4818561.Malik.2016.zip (1.3GB) | README |
| Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Traylor M, et al. Neurology. 2016 Jan 12;86(2):146-53. doi: 10.1212/WNL.0000000000002263. PMID:26674333 |
26674333.Traylor.2016.txt.gz (101MB) | README |
| Multi-ethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Verhaaren BF, et al. Circ Cardiovasc Genet. 2015 Apr;8(2):398-409. doi: 10.1161/CIRCGENETICS.114.000858. PMID:25663218 |
Information for download | |
| Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Kilarski LL, et al. Neurology. 2014 Aug 19;83(8):678-85. doi: 10.1212/WNL.0000000000000707. PMID:25031287 |
Information for download | |
| A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. Traylor M, et al. PLoS Genet. 2014 Jul 31;10(7):e1004469. doi: 10.1371/journal.pgen.1004469. PMID:25078452 |
Information for download | |
| Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Traylor M, et al. Lancet Neurol. 2012 Nov;11(11):951-62. doi: 10.1016/S1474-4422(12)70234-X. PMID:23041239 |
3490334.Traylor.2012.zip (307MB) | README |
| Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Holliday EG, et al. Nat Genet. 2012 Oct;44(10):1147-51. doi: 10.1038/ng.2397. PMID:22941190 |
Information for download | |
| Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke International Stroke Genetics Consortium, et al. Nat Genet. 2012 Feb 5;44(3):328-33. doi: 10.1038/ng.1081. PMID:22306652 |
Information for download | |
| Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Fornage M, et al. Ann Neurol. 2011 Jun;69(6):928-39. doi: 10.1002/ana.22403. PMID:21681796 |
Information for download (More information at the CHARGE Consortium website) |
GWAS summary statistics from studies incorporated into the CDKP
The table is ordered by publication date in reverse chronological order.
| Dataset name in CDKP | Publication | Phenotypes | Download links |
|---|---|---|---|
| Intracranial aneurysm GWAS | Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Bakker MK, et al. Nat Genet. 2020 doi: 10.1038/s41588-020-00725-7 |
Aneurysm | |
| Cerebral Small Vessel Disease Multi-Trait Analysis of GWAS | Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Chung J, et al. Brain. 2019 Oct 1;142(10):3176-3189. doi: 10.1093/brain/awz233. PMID:31430377 |
Stroke |
Intracerebral hemorrhage or small vessel ischemic stroke summary statistics Lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics Non-lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics |
| GISCOME ischemic stroke outcome GWAS | Genome-wide Association Meta-Analysis of Functional Outcome After Ischemic Stroke. Söderholm M, et al. Neurology. 2019 Mar 19;92(12):e1271-e1283. doi: 10.1212/WNL.0000000000007138. PMID:30796134 |
Ischemic stroke outcome |
mRS 0-1 vs 2-6 at 3 months adj stroke severity mRS 0-2 vs 3-6 at 3 months adj stroke severity |
| Cerebral WMHV GWAS 2019 | Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226). Traylor M, et al. Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952. PMID:30659137 |
MRI Traits | Summary statistics | README |
| ICH GWAS | Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. Woo D, et al. Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012. PMID:24656865 |
Hemorrhagic stroke | Summary statistics (350MB) | README |