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Publications
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction.
Ntalla I, Weng L-C, et al.
Nat Commun. 2020 May 21;11(1):2542. doi: 10.1038/s41467-020-15706-x.
PMID:32439900
Phenotypes
- PR interval
Subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 2216 | Age, Gene/Environment Susceptibility Study (AGES) | European |
| 1505 | The Amish Complex Disease Research Program (AMISH) | European |
| 8038 | Atherosclerosis Risk in Communities (ARIC) | European |
| 2455 | Atherosclerosis Risk in Communities (ARIC) | African American |
| 485 | Brazilian Bambui Cohort Study of Ageing (Bambui) | Brazilian |
| 320 | BioMe BioBank Program (BioME-Omni) | European |
| 773 | BioMe BioBank Program (BioME-Omni) | African American |
| 1137 | BioMe BioBank Program (BioME-Omni) | Hispanic |
| 1310 | British Genetics of Hypertension (BRIGHT) | European |
| 3461 | Broad AF study (controls) | European |
| 2140 | Cardiology and Metabolic Patient Cohort (MGH CAMP) | European |
| 4205 | Cooperative Health Research in South Tyrol (CHRIS) | European |
| 2974 | Cardiovascular Health Study (CHS) | European |
| 644 | Cardiovascular Health Study (CHS) | African American |
| 293 | CROATIA-Korcula | European |
| 347 | CROATIA-Split | European |
| 80085 | ODE Electrocardiograph study (DeCODE) | European |
| 1979 | Erasmus Rucphen Family Study (ERF) | European |
| 7834 | Framingham Heart Study (FHS) | European |
| 1215 | The Finnish Cardiovascular Study (Metabochip) (FINCAVAS-MC) | European |
| 1666 | Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP) | European |
| 941 | Genetic Regulation of Arterial Pressure of Humans in the Community (GRAPHIC) | European |
| 9087 | Generation Scotland: Scottish Family Health Study (GS-SFHS) | European |
| 4898 | Health 2000 (H2000) | European |
| 11686 | Hispanic Community Health Survey/Study of Latinos (HCHSSOL) | Hispanic |
| 326 | INGI-Carlantino (INGI-CARL) | European |
| 981 | GI - Friuli Venezia Giulia (INGI-FVG) | European |
| 2683 | Jackson Heart Study (JHS) | African American |
| 2724 | Kooperative Gesundheitsforschung in der Region Augsburg (KORAF3) | European |
| 3457 | Kooperative Gesundheitsforschung in der Region Augsburg (KORAS4) | European |
| 12823 | LifeLines Cohort Study & Biobank (Lifelines) | European |
| 2620 | Multi-Ethnic Study of Atherosclerosis (MESA) | European |
| 1618 | Multi-Ethnic Study of Atherosclerosis (MESA) | African American |
| 763 | Multi-Ethnic Study of Atherosclerosis (MESA) | East Asian |
| 602 | Microisolates in South Tyrol Study (MICROS) | European |
| 5423 | Netherlands Epidemiology of Obesity (NEO) | European |
| 1785 | The Orkney Complex Disease Study (ORCADES) | European |
| 834 | Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) | European |
| 3377 | Prevention of REnal and Vascular ENd-stage Disease (PREVEND) | European |
| 4227 | The PROspective Study of Pravastatin in the Elderly at Risk for vascular disease (PROSPER) | European |
| 4587 | Rotterdam Study cohort 1 (RS1) | European |
| 1897 | Rotterdam Study cohort 2 (RS2) | European |
| 2873 | Rotterdam Study cohort 3 (RS3) | European |
| 5799 | SardiNIA (SardiNIA) | European |
| 2699 | Study of Health in Pomerania (SHIP-0) | European |
| 941 | Study of Health in Pomerania - Trend (SHIP-T) | European |
| 3085 | TwinsUK (TwinsUK) | European |
| 60543 | UK Biobank (UK Biobank) | European |
| 594 | ppsala Longitudinal Study of Adult Men (ULSAM) | European |
| 3596 | Women's Health Initiative (WHI-GARNET) | European |
| 750 | Women's Health Initiative (WHI-GECCO) | European |
| 821 | Women's Health Initiative (WHI-HIPFX) | European |
| 986 | Women's Health Initiative (WHI-LLS) | European |
| 2011 | Women's Health Initiative (WHI-MOPMAP) | European |
| 2011 | Women's Health Initiative (WHI-WHIMS) | European |
| 1725 | The Cardiovascular Risk in Young Finns Study (YFS) | European |
Experiment summary
This study is a meta-analysis of associations with the electrocardiographic PR interval. Results are available for the overall multi-ancestry sample set and for a European ancestry subset.
Dataset ID
GWAS_PRw1000GP