Publication
Translational genomics of osteoarthritis in 1,962,069 individuals.
Hatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald MLN, et al.
Nature. 2025 May;641(8065):1217–1224. doi: 10.1038/s41586-025-08771-z.
PMID: 40205036
Phenotypes
- Osteoarthritis
- Finger osteoarthritis
- Hand Osteoarthritis
- Osteoarthritis (hip)
- Osteoarthritis of the hip or knee
- Knee osteoarthritis
- Spine osteoarthritis
- Osteoarthritis (with total hip replacement)
- Thumb osteoarthritis
- Osteoarthritis of the hip or knee (with total joint replacement)
- Osteoarthritis (with total knee replacement)
Experiment summary
This study reports the largest osteoarthritis GWAS meta-analysis to date (up to 489,975 cases and 1,472,094 controls of mixed ancestry), identifying 962 independent associations (513 novel), integrating multi-omics to prioritize ~700 effector genes, and highlighting drug repurposing opportunities.
Dataset ID
Hatzikotoulas2025_OA_Mixed