CVDKP Downloads

Polygenic Scores

GWAS Summary Statistic Downloads

Other Data Downloads


Polygenic Scores

Download a polygenic score file and the accompanying GWAS summary statistics for circulating lipoprotein(a) concentrations, as described in this study:

Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations.
Dron JS, Wang M, et al.
Circ Genom Precis Med. 2021 Feb;14(1):e003182. doi: 10.1161/CIRCGEN.120.003182.

Polygenic score for lipoprotein(a) (612 KB)   |   Lp(a) GWAS summary statistics   |    README for summary statistics


Download a file containing 6,630,150 variants and associated weights for the polygenic score validated in South Asian populations, as described in this study:

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians
Wang M, et al.
J. Amer. Coll. Cardiol. 2020 76(6). doi: 10.1016/j.jacc.2020.06.024

Coronary artery disease risk (55 GB)

Genome-wide polygenic scores are made freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering or send an e-mail to: partnering@broadinstitute.org.


Download a list of variants and weights comprising a genome-wide polygenic score for body mass index and obesity, as described in:

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
Khera AV, Chaffin M, et al.
Cell. 2019 Apr 18;177(3):587-596.e9. doi: 10.1016/j.cell.2019.03.028

Body mass index and obesity (89 MB)

Genome-wide polygenic scores are made freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering or send an e-mail to: partnering@broadinstitute.org.


Download lists of variants and weights comprising genome-wide polygenic scores for five complex diseases, as described in:

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Khera AV, Chaffin M, et al.
Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z

Atrial fibrillation (297.3 MB) | Breast cancer (253 KB) | Coronary artery disease (292.9 MB) | Inflammatory bowel disease (305.1 MB) | Type 2 diabetes (305.6 MB)

Genome-wide polygenic scores are made freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering or send an e-mail to: partnering@broadinstitute.org.


Download a list of SNPs (.txt file) comprising the polygenic risk score for lifetime risk of atrial fibrillation, as developed in this study:

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation
Weng LC, et al. Circulation. 2017 Nov 12. pii: CIRCULATIONAHA.117.031431. doi: 10.1161/CIRCULATIONAHA.117.031431

 

GWAS Summary Statistic Downloads

 

Dataset name in CVDKP Publication Phenotypes Download
(Dataset not yet integrated into CVDKP) Deep learning enables genetic analysis of the human thoracic aorta.
Pirruccello JP, et al.

Nat Genet 2021, in press.

BioRxiv preprint

Aortic diameter Summary statistics - ascending aorta diameter |
Summary statistics - descending aorta diameter
| README
(Dataset not yet integrated into CVDKP) Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations.
Dron JS, Wang M, et al.

Circ Genom Precis Med. 2021 Feb;14(1):e003182. doi: 10.1161/CIRCGEN.120.003182
PMID:33522245
Circulating Lp(a) concentration Summary statistics | README | Polygenic score for lipoprotein(a)
(Dataset not yet integrated into CVDKP) Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.
Weng L-C, Hall AW, et al.

Circ Genom Precis Med. 2020 Oct;13(5):387-395. doi: 10.1161/CIRCGEN.119.002874.
PMID:32822252
P-wave duration Summary statistics and README
PR interval 1000G GWAS Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction.
Ntalla I, Weng L-C, et al.

Nat Commun. 2020 May 21;11(1):2542. doi: 10.1038/s41467-020-15706-x.
PMID:32439900
ECG traits Summary statistics - all | README
Summary statistics - Europeans | README
UK Biobank Cardiac MRI LV GWAS Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.
Pirruccello J, et al.

Nat Commun. 2020 May 7;11(1):2254. doi: 10.1038/s41467-020-15823-7.
PMID:32382064
Cardiovascular Summary statistics for:
Left ventricular end-diastolic volume |
Left ventricular end-diastolic volume  (BSA-indexed) |
Left ventricular ejection fraction |
Left ventricular end-systolic volume |
Left ventricular end-systolic volume (BSA-indexed) |
Stroke volume |
Stroke volume (BSA-indexed) |
README
UK Biobank atrial fibrillation exome sequence analysis Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.
Choi SH, Jurgens SJ, et al.

Circ Res, 126 (2), 200-209 2020 Jan 17. doi: 10.1161/CIRCRESAHA.119.315686.
PMID:31691645
Atrial fibrillation Gene-level association scores | README
HERMES Heart Failure GWAS Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure.
Shah S, Henry A, et al.

Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5.
PMID:31919418
Heart failure Summary statistics | README
Early-onset AF TOPMed WGS Association between titin loss-of-function variants and early-onset atrial fibrillation.
Choi SH, et al.

JAMA. 2018 Dec 11;320(22):2354-2364. doi:10.1001/jama.2018.18179.
PMID:30535219
Atrial fibrillation Summary statistics | README
UK Biobank Heart Failure GWAS Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery.
Aragam KG, et al.

Circulation. 2018 Nov 11. doi: 10.1161/CIRCULATIONAHA.118.035774.
PMID:30586722
Cardiovascular Summary statistics | README
Albuminuria GWAS Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.
Haas ME, et al.

Am J Hum Genet. 2018 Oct 4;103(4):461-473. doi: 10.1016/j.ajhg.2018.08.004.
PMID:30220432
Renal Summary statistics | README
2018 AF HRC GWAS Multi-ethnic genome-wide association study for atrial fibrillation.
Roselli C, et al.

Nat Genet. 2018 Sep;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.
PMID:29892015
Atrial fibrillation Summary statistics | README
PR interval exome chip analysis 



Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.
Lin H, et al.
Circ Genom Precis Med. 2018 May;11(5):e002037. doi: 10.1161/CIRCGEN.117.002037.
PMID:29748316
ECG traits Summary statistics | README
PWI GWAS 



Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.
Christophersen IE, et al.
Circ Cardiovasc Genet. 2017 Aug;10(4). pii: e001667. doi: 10.1161/CIRCGENETICS.116.001667.
PMID:28794112
ECG traits Summary statistics | README
2017 AFGen GWAS (subset of 2018 AF HRC GWAS) Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
Christophersen IE, et al.

Nat Genet. 2017 Jun;49(6):946-952. doi: 10.1038/ng.3843.
PMID:28416818
Atrial fibrillation Summary statistics | README

 

Other Data Downloads

PubMed ID Title Download files README files
  ATAC-seq data from human adult left atrium/cardiomyocytes Download files README