T2DKP Summary Statistic Downloads

This page lists datasets whose summary statistic files are hosted at the T2DKP.

Dataset name in T2DKP Publication (ordered by publication date, most recent first) Phenotypes Download site
GERA age-related GWAS The impact of non-additive genetic associations on age-related complex diseases.
Guindo-Martínez M, et al.
Submitted for publication, 2020.
BioRxiv
Multiple age-related diseases

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Smoking-Genotype Interaction for T2D and FG Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Wu P, et al.
PLoS One 2020 May 7;15(5):e0230815. doi: 10.1371/journal.pone.0230815.
PMID:32379818
Glycemic

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PR interval 1000G GWAS Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction.
Ntalla I, Weng L-C, et al..
Nature Communications (2020) 11:2542 doi:10.1038/s41467-020-15706-x
ECG Traits

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UK Biobank Cardiac MRI LV GWAS Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.
Pirruccello J, et al.

Nat Commun. 2020 May 7;11(1):2254. doi: 10.1038/s41467-020-15823-7.
PMID:32382064
Cardiovascular Summary statistics for:
Left ventricular end-diastolic volume |
Left ventricular end-diastolic volume  (BSA-indexed) |
Left ventricular ejection fraction |
Left ventricular end-systolic volume |
Left ventricular end-systolic volume (BSA-indexed) |
Stroke volume |
Stroke volume (BSA-indexed) |
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AGEN and DIAMANTE T2D GWAS Identification of type 2 diabetes loci in 433,540 East Asian individuals.
Spracklen C, Horikoshi M, Kim YJ, Lin K, et al.
Nature 2020.
https://doi.org/10.1038/s41586-020-2263-3
Type 2 diabetes

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UK Biobank dietary habit GWAS Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.
Cole JB, Florez JC, Hirschhorn JN.
Nat Commun. 2020; 11: 1467. doi: 10.1038/s41467-020-15193-0.
PMID:32193382
Dietary habits

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UK Biobank atrial fibrillation exome sequence analysis Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.
Choi SH, Jurgens SJ, et al.

Circ Res, 126 (2), 200-209 2020 Jan 17. doi: 10.1161/CIRCRESAHA.119.315686.
PMID:31691645
Atrial fibrillation Gene-level association scores | README
HERMES Heart Failure GWAS Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure.
Shah S, Henry A, et al.

Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5.
PMID:31919418
Cardiovascular

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JDRF Diabetic Nephropathy Collaborative Research Initiative GWAS Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Salem, R.M., et al.
J Am Soc Nephrol. 2019 Oct;30(10):2000-2016. doi: 10.1681/ASN.2019030218.
PMID:31537649
Renal Download files
Diabetic retinopathy GWAS Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Pollack S, et al. Diabetes. 2019 Feb; 68(2): 441–456. doi: 10.2337/db18-0567. PMID:30487263 Ocular Download African American ancestry files
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SIGMA exome chip analysis A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Mercader M, et al., Diabetes 2017 Nov;66(11):2903-2914. doi: 10.2337/db17-0187. PMID:28838971 Glycemic Download files
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GWAS SIGMA Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. SIGMA Type 2 Diabetes Consortium, et al., Nature. 2014 Feb 6;506(7486):97-101. doi: 10.1038/nature12828. PMID:24390345 Glycemic Download files
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AMP T2D-GENES exome sequence analysis: SIGMA cohorts Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. SIGMA Type 2 Diabetes Consortium, et al., JAMA 2014 Jun 11;311(22):2305-14. doi: 10.1001/jama.2014.6511. PMID:24915262 Glycemic Download files
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