T2DKP Summary Statistic Downloads

This page lists datasets that are incorporated into the T2DKP for which summary statistic files are also available for download.

Dataset name in T2DKP Publication (ordered by publication date, most recent first) Phenotypes Download site
HERMES Heart Failure GWAS Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure. Shah S, Henry A, et al.
, Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5. PMID:31919418 Cardiovascular

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JDRF Diabetic Nephropathy Collaborative Research Initiative GWAS Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. Salem, R.M., et al.
, J Am Soc Nephrol. 2019 Oct;30(10):2000-2016. doi: 10.1681/ASN.2019030218. PMID:31537649 Renal Download files (see the JDRF Diabetic Nephropathy Collaborative Research Initiative GWAS section)
CKDGen GWAS - stratified UACR and microalbuminuria associations Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Teumer, A., et al.
, Nat Commun. 2019 Sep 11;10(1):4130. doi: 10.1038/s41467-019-11576-0. PMID:31511532 Renal Download site
FinnMetSeq exome sequence analysis Exome sequencing of Finnish isolates enhances rare-variant association power. Locke AE, et al., Nature. 2019 Aug;572(7769):323-328. doi: 10.1038/s41586-019-1457-z. PMID:31367044 Multiple Download site
CKDGen GWAS A catalog of genetic loci associated with kidney function from analyses of a million individuals. Wuttke, M., et al.
, Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. PMID:31152163 Renal Download site
GIANT 2018 Body Fat Distribution exome chip analysis Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Justice, A.E., et al., Nat Genet. 2019 Mar;51(3):452-469. doi: 10.1038/s41588-018-0334-2. PMID:30778226 Anthropometric Download site
GEFOS eBMD and fracture GWAS An atlas of genetic influences on osteoporosis in humans and mice. Morris, J. A., et al.
, Nat Genet. 2019 Feb;51(2):258-266. doi: 10.1038/s41588-018-0302-x. PMID:30598549 Musculoskeletal Download site
COGENT-Kidney Consortium eGFR GWAS Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. Morris, A.P., et al.
, Nat Commun. 2019 Jan 3;10(1):29. doi: 10.1038/s41467-018-07867-7. PMID:30604766 Renal Download site
UK Biobank T2D GWAS (DIAMANTE-Europeans Sept 2018)
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Mahajan, A., et al.
, Nat Genet. 2018 Nov;50(11):1505-1513. doi: 10.1038/s41588-018-0241-6. PMID:30297969 Glycemic Download site
GIANT UK Biobank GWAS Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Yengo, L., et al., Hum Mol Genet. 2018 Aug 16. doi: 10.1093/hmg/ddy271. PMID:30124842 Anthropometric Download site
SUMMIT Diabetic Kidney Disease GWAS A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. van Zuydam, N.R., et al., Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914. PMID:29703844 Renal Download site
ExTexT2D exome chip analysis Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Mahajan A., et al.
, Nat Genet. 2018 Apr;50(4):559-571. doi: 10.1038/s41588-018-0084-1. PMID:29632382 Glycemic Download site
Biobank Japan GWAS
Biobank Japan GWAS, females
Biobank Japan GWAS, males
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Kanai, M., et al.
, Nat Genet. 2018 Mar;50(3):390-400. doi: 10.1038/s41588-018-0047-6. PMID:29403010 Multiple Download site
GIANT 2018 BMI, Height exome chip analysis Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot, V., et al., Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. PMID:28490609 Anthropometric Download site
70KforT2D GWAS Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Bonàs-Guarch, S., et al.
, Nat Commun. 2018 Jan 22;9(1):321. doi: 10.1038/s41467-017-02380-9. PMID:29358691 Glycemic Download site
GLGC exome chip analysis Exome-wide association study of plasma lipids in >300,000 individuals. Liu, D.J., et al., Nat Genet. 2017 Dec;49(12):1758-1766. doi: 10.1038/ng.3977. PMID:29083408 Lipids Download site
DIAGRAM 1000G GWAS An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Scott, R.A., et al.
, Diabetes. 2017 Nov;66(11):2888-2902. doi: 10.2337/db16-1253. PMID:28566273 Glycemic Download site
Joint T2D-CHD GWAS Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Zhao, W., et al.
, Nat Genet. 2017 Oct;49(10):1450-1457. doi: 10.1038/ng.3943. PMID:28869590 Glycemic, Cardiovascular Download

summary statistics for T2D meta-analysis | summary statistics for bivariate analysis

UK Biobank CardioMetabolic Consortium CHD GWAS Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nelson, C.P., et al.
, Nat Genet. 2017 Sep;49(9):1385-1391. doi: 10.1038/ng.3913. PMID:28714975 Cardiovascular Download site
MAGIC HbA1c GWAS (all ancestries) 

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Wheeler, E., et al.
, PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383. PMID:28898252 Glycemic Download site
IVGTT-Based Insulin Secretion GWAS A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Wood, A.R., et al.
, Diabetes. 2017 Aug;66(8):2296-2309. doi: 10.2337/db16-1452. PMID:28490609 Glycemic Download site
CKDGen 1000G GWAS - eGFRcys associations 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Gorski, M., et al.
, Sci Rep. 2017 Apr 28;7:45040. doi: 10.1038/srep45040. PMID:28452372 Renal Download site
GIANT GWAS - stratified by physical activity Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. Graff, M., et al., PLoS Genet. 2017 Apr 27;13(4):e1006528. doi: 10.1371/journal.pgen.1006528. PMID:28448500 Anthropometric Download site
VATGen GWAS Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Chu A.Y., et al.
, Nat Genet. 2017 Jan;49(1):125-130. doi: 10.1038/ng.3738. PMID:27918534 Glycemic Download site

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Walford, G.A., Gustafsson, S., Rybin, D., et al.
, Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. PMID:27416945 Glycemic Download site
gnomAD exomes
gnomAD whole genomes
Analysis of protein-coding genetic variation in 60,706 humans. Lek, M., et al., Nature. 2016 Aug 18;536(7616):285-91. doi: 10.1038/nature19057. PMID:27535533 No phenotype Download site
AAGILE GWAS Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Liu, C.T., et al.
, Am J Hum Genet. 2016 Jul 7;99(1):56-75. doi: 10.1016/j.ajhg.2016.05.006. PMID:27321945 Glycemic Download site
Leptin GWAS Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Kilpeläinen, T.O., et al.
, Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494. PMID:26833098 Glycemic Download site
Body Fat Percentage GWAS New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu, Y., et al.
, Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495. PMID:26833246 Anthropometric Download site
DIAGRAM Trans-ethnic meta-analysis Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Gaulton, K.J., et al.
, Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. PMID:26551672 Glycemic Download site
1000 Genomes A global reference for human genetic variation. 1000 Genomes Project Consortium, et al.
, Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393. PMID:26432245 No phenotype Download site
GIANT Anthropometric 2015 Waist GWAS New genetic loci link adipose and insulin biology to body fat distribution. Shungin, D., et al., Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132. PMID:25673412 Anthropometric Download site
SIGMA exome chip analysis
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. SIGMA Type 2 Diabetes Consortium, et al., Nature. 2014 Feb 6;506(7486):97-101. doi: 10.1038/nature12828. PMID:24390345 Glycemic Download site
GLGC GWAS Discovery and refinement of loci associated with lipid levels. Willer, C.J., et al., Nat Genet. 2013 Nov;45(11):1274-83. doi: 10.1038/ng.2797. PMID:24097068 Lipids Download site
Heart Rate GWAS Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed, M., et al., Nat Genet. 2013 Jun;45(6):621-31. doi: 10.1038/ng.2610. PMID:23583979 Cardiovascular Download site
Global Urate Genetics Consortium GWAS Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Köttgen, A., et al., Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. PMID:23263486 Metabolite Download site
GIANT GWAS FTO genotype is associated with phenotypic variability of body mass index. Yang, J., et al., Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401. PMID:22982992 Anthropometric Download site
MAGIC Metabochip GWAS 

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Scott, R.A., et al.
, Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385. PMID:22885924 Glycemic Download site
ADIPOGen GWAS Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani, Z., et al.
, PLoS Genet. 2012;8(3):e1002607. doi: 10.1371/journal.pgen.1002607. PMID:22479202 Glycemic Download site
Early Growth Genetics Consortium GWAS A genome-wide association meta-analysis identifies new childhood obesity loci. Bradfield, J.P., et al.
, Nat Genet. 2012 May;44(5):526-31. doi: 10.1038/ng.2247. PMID:22484627 Anthropometric Download site
Liver Function GWAS Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Chambers, J.C., et al.
, Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970. PMID:22001757 Hepatic Download site