Publications
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC).
Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5.
PMID: 26708676
Phenotypes
- all ischemic stroke
- CCS causative cardio-aortic embolism-major
- CCS causative cryptogenic with cardioembolism minor
- CCS causative incomplete + unclassified
- CCS causative large artery atherosclerosis
- CCS causative small artery occlusion
- CCS causative undetermined
- CCS phenotype cardio-aortic embolism-major
- CCS phenotype cryptogenic
- CCS phenotype large artery atherosclerosis-major
- CCS phenotype small artery occlusion-major
- TOAST cardio-aortic embolism
- TOAST large artery atherosclerosis
- TOAST small artery occlusion
- TOAST other undetermined
Experiment summary
This study was a trans-ancestry analysis of genetic associations with ischemic stroke and its sub-types in 16,851 ischemic stroke cases and 32,473 controls. Stroke sub-types were classified using the Causative Classification of Stroke (CCS) and Trial of Org 10172 in Acute Stroke Treatment (TOAST) systems. Cases were defined as ischemic stroke cases of European or African descent with imaging confirmation of the absence of hemorrhagic stroke.
Dataset ID
SiGN2016_Stroke_Mixed