DNA methylation biomarker 2021 GWAS: trans-ancestry

Summary statistics are available for download from the GWAS Catalog.

Publications

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
McCartney DL, et al.
Genome Biol. 2021 Jun 29;22(1):194. doi: 10.1186/s13059-021-02398-9.
PMID: 34187551

Phenotypes

  • DNA methylation GrimAge acceleration
  • DNA methylation Hannum age acceleration
  • DNA methylation PhenoAge acceleration
  • Intrinsic epigenetic age acceleration
  • DNA methylation-estimated plasminogen activator inhibitor-1 levels

Experiment summary

This study was a trans-ancestry meta-analysis of genetic associations for DNA methylation markers of aging in 40,615 participants of European and African American ancestry.

Dataset ID
McCartney2021_EAA_Mixed