Download URL: https://www.magicinvestigators.org/downloads/
Publications
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Wheeler E, et al.
PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383
Phenotypes
- HbA1c
Subjects
| Samples | Cohort (Click to view exclusion criteria) | Ancestry |
|---|---|---|
| 1,687 | LOLIPOP_IA317 | South Asian |
| 1,146 | LOLIPOP_IA610_cases | South Asian |
| 2,753 | LOLIPOP_IA610_controls | South Asian |
| 482 | LOLIPOP_IA_P | South Asian |
| 1,726 | Singapore SINDI | South Asian |
| 1,302 | The Pakistan Risk Of Myocardial Infarction Study (PROMIS) | South Asian |
Project
MAGIC (the Meta-Analyses of Glucose and Insulin-related traits Consortium) represents a collaborative effort to combine data from multiple GWAS to identify additional loci that impact on glycemic and metabolic traits.
Experiment summary
This study is an ancestry-specific and transethnic genome-wide meta-analysis of associations with HbA1c in individuals from 82 cohorts of European, African American, East Asian, and South Asian (N=8,874) ancestry. HbA1c trait values are untransformed and adjusted for age, sex and study-specific covariates.