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Apnea-hypopnea index - all associations
Apnea-hypopnea index - females
Apnea-hypopnea index - males
Apnea-hypopnea index - European Americans
Apnea-hypopnea index - European Americans, females
Apnea-hypopnea index - European Americans, males
Apnea-hypopnea index in NREM sleep - all associations
Apnea-hypopnea index in NREM sleep - females
Apnea-hypopnea index in NREM sleep - males
Apnea-hypopnea index in NREM sleep - European Americans
Apnea-hypopnea index in NREM sleep - European Americans, females
Apnea-hypopnea index in NREM sleep - European Americans, males
Apnea-hypopnea index in REM sleep - all associations
Apnea-hypopnea index in REM sleep - females
Apnea-hypopnea index in REM sleep - males
Apnea-hypopnea index in REM sleep - European Americans
Apnea-hypopnea index in REM sleep - European Americans, females
Apnea-hypopnea index in REM sleep - European Americans, males
Publications
Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.
Chen H, et al.
Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401. doi: 10.1165/rcmb.2017-0237OC
Phenotypes
- Apnea-Hypopnea Index
- Apnea-Hypopnea Index in REM sleep
- Apnea-Hypopnea Index in NREM sleep
Subjects
| Samples | Cohort | Ancestry |
|---|---|---|
| 1,463 | Atherosclerosis Risk in Communities Study (ARIC) | European |
| 731 | Cleveland Family Study (CFS) | African American |
| 702 | Cleveland Family Study (CFS) | European |
| 646 | Framingham Heart Study (Framingham) | European |
| 11,317 | Hispanic Community Health Study/Study of Latinos (HCHS/SOL) | Hispanic |
| 490 | Multi-Ethnic Study of Atherosclerosis (MESA) | African American |
| 228 | Multi-Ethnic Study of Atherosclerosis (MESA) | Asian American |
| 707 | Multi-Ethnic Study of Atherosclerosis (MESA) | European |
| 458 | Multi-Ethnic Study of Atherosclerosis (MESA) | Hispanic |
| 782 | Starr County Health Studies (Starr) | European |
| 2,209 | Osteoporotic Fractures in Men Study (MrOS) | European |
Experiment summary
This study determined genetic associations with the Apnea-Hypopnea Index (AHI), a count of the number of total (apnea) and partial (hypopnea) breathing pauses per hour. Hypopnea was defined as having 3% or greater oxyhemoglobin desaturation. All phenotypes were rank-normalized, adjusting for age, age2, sex, age x sex, BMI, and BMI2. Mixed linear models (GEMMA) were used and were adjusted for genomic-control at a cohort level before running METAL.