CKDGen 1000G GWAS - eGFRcys associations

Dataset

All CKDGen GWAS datasets draw upon overlapping sample sets.

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Publications

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Gorski M, et al.
Sci Rep. 2017 Apr 28;7:45040. doi: 10.1038/srep45040

New loci associated with kidney function and chronic kidney disease.
Köttgen A, et al.
Nat Genet. 2010 May;42(5):376-84. doi: 10.1038/ng.568

Dataset phenotypes

  • eGFR-cys (serum cystatin C)

Dataset subjects

Samples (eGFR-creat) Samples (eGFR-cys) Cohort Ancestry
6,431 n/a Three-City Study (3C) European
3,219 n/a Age, Gene/Environment Susceptibility-Reykjavik Study (AGES) European
9,038 7,151 Atherosclerosis Risk in Communities study (ARIC) European
829 n/a Austrian Stroke Prevention Study (ASPS) European
2,437 n/a Blue Mountains Eye Study (BMES) European
1,092 n/a Italian Network on Genetic Isolates – Cilento (CILENTO) European
5,409 n/a Cohort Lausannoise (COLAUS) European
4,437 1,037 Estonian Genome Center University of Tartu (EGCUT1) European
1,018 n/a Estonian Genome Center University of Tartu (EGCUT2) European
3,838 521 Family Heart Study (FamHS) European
3,051 2,992 Framingham Heart Study (FHS) European
450 532 GENetics of DIAbetic Nephropathy study (GENDIAN) European
1,661 1,661 Health Aging and Body Composition Study (HABC) European
2,113 n/a Hunter Community Study (HCS) European
818 n/a Health Professionals Follow-Up Study (HPFS) European
412 n/a Italian Network on Genetic Isolates – Carlantino (INGI-CARLANTINO) European
848 n/a Italian Network on Genetic Isolates – Friuli Venezia-Giulia (INGI-FVG) European
1,754 n/a Italian Network on Genetic Isolates – Val Borbera (INGI-VAL BORBERA) European
440 n/a Mount Sinai BioMe Biobank Program (IPM I) European
1,307 n/a Mount Sinai BioMe Biobank Program (IPM II) European
3,095 1,642 Cooperative Health Research in the Augsburg Region (KORA-F3) European
2,936 1,811 Cooperative Health Research in the Augsburg Region (KORA-F4) European
13,386 n/a LIFELINES European
2,520 2,520 Multi-Ethnic Study of Atherosclerosis (MESA) European
1,185 n/a Microisolates in South Tyrol study (MICROS) European
786 n/a Nurses' Health Study (NHS) European
563 n/a The Northern Swedish Population Health Study (NSPHS) European
4,595 n/a The Rotterdam Study (RS I) European
1,444 n/a Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) European
3,210 3,210 The Study of Health in Pomerania (SHIP) European
986 986 The Study of Health in Pomerania (SHIP-TREND) European
23,186 n/a Women’s Genome Health Study (WGHS) European
2,023 n/a Young Finns Study (YFS) European

Experiment summary

This study is a a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data.

Project

Chronic Kidney Disease Genetics Consortium (CKDGen)

CKDGen is a consortium of researchers investigating genetic loci associated with kidney function and disease.

Dataset ID
GWAS_CKDGenConsortiumGFRcys