| Cases |
Controls |
Cohort (Click to view heart failure definition) |
Ancestry |
| 1,835 |
7,476 |
ARIC
| Heart failure definition |
| Incident HF was defined as the first HF hospitalization or presence of HF code on death certificate since baseline visit through 2013. Discharge records and death certificates that showed a HF code in any position with International Classification of Diseases Code, Ninth Revision (ICD-9) code 428.x, and deaths with ICD-9/10 codes of either 428.x or I50 were considered as HF. Prevalent Heart Failure was ascertained at first visit. If the participant reported to have taken any medication for heart failure, or qualifies for the Gothenburg Criteria then the participant had prevalent heart failure at baseline. |
|
European |
| 1,561 |
954 |
BIOSTAT-CHF (Validation)
| Heart failure definition |
| Heart failure was defined based on physician diagnosis, previous documented admission with heart failure requiring diuretic treatment, treatment with furosemide ≥20 mg/day or equivalent. |
|
European |
| 1,123 |
2,145 |
CHS
| Heart failure definition |
| Incident HF events were identified by self-report or administrative data validated by physician’s review of medical records, as described in previous reports (PMID: 1669507). In brief, heart failure was defined on the basis of cardiomegaly and pulmonary edema on chest X-ray; or dilated ventricle and wail-motion abnormalities by echocardiography or contrast ventriculography; or congestive failure diagnosed by physician, plus receiving medical treatment (diuretic plus either digitalis, vasodilator or angiotensin converting enzyme inhibitor). |
|
European |
| 636 |
2,215 |
COGEN
| Heart failure definition |
| Inclusion criteria: patients ≥ 18 years, LVEF < 40% or symptoms of clinical HF assessed by a physician including NYHA > 1 Exclusion criteria: patients with cardiac valvular pathology (e.g. aortic stenosis), HTx, PAH or other structural heart disease |
|
European |
| 13,200 |
367,730 |
deCODE
| Heart failure definition |
| Heart failure case status was assigned based on ICD-9 or ICD-10 codes for discharge diagnoses (ICD-10: I50 and subcodes, ICD-9: 428 and subcodes). |
|
European |
| 5,656 |
31,026 |
DiscovEHR |
European |
| 243 |
1,693 |
EGCUT 370
| Heart failure definition |
| Heart failure status was assigned based on ICD-10: I50 and subcodes. |
|
European |
| 605 |
4,743 |
EGCUT Exome
| Heart failure definition |
| Heart failure status was assigned based on ICD-10: I50 and subcodes. |
|
European |
| 1,851 |
4,273 |
EGCUT Omni
| Heart failure definition |
| Heart failure status was assigned based on ICD-10: I50 and subcodes. |
|
European |
| 1,094 |
886 |
EPHESUS
| Heart failure definition |
| Patients were recruited 3 to 14 days after acute myocardial infarction according to the following critera: acute myocardial infarction as documented according to standard criteria; left ventricular dysfunction as documented by a left ventricular ejection fraction of 40 percent or lower on echocardiography, radionuclide angiography, or angiography of the left ventricle after the index acute myocardial infarction and before randomization; and heart failure as documented by the presence of pulmonary rales, chest radiography showing pulmonary venous congestion, or the presence of a third heart sound. In patients with diabetes who met the criteria for left ventricular dysfunction after acute myocardial infarction, symptoms of heart failure did not have to be demonstrated, since such patients have an increased risk of cardiovascular events similar to that of nondiabetic patients with symptoms of heart failure. |
|
European |
| 1,687 |
17,631 |
EPIC-Norfolk
| Heart failure definition |
| Heart failure definition was based on hospital admission or death record listing Heart failure code - ICD-10: I50 and subcodes |
|
European |
| 476 |
3,290 |
FHS
| Heart failure definition |
| Criteria for defining heart failure in the FHS have been described previously (PMID: 5122894, 16837677). In brief, heart failure was considered to be present if two major or one major plus two minor criteria were present in the absence of an alternative explanation for the symptoms and signs. Major criteria are defined as paroxysmal nocturnal dyspnea, orthopnea, jugular venous distention, hepatojugular reflux, pulmonary rales, radiographic evidence of cardiomegaly, acute pulmonary edema, third heart sound, central venous pressure > 16 cm of water, and weight loss > 4.5 kg during first 5 days of treatment for suspected heart failure. Minor criteria are defined as bilateral ankle edema, nocturnal cough, dyspnea on ordinary exertion, hepatomegaly, pleural effusion, and heart rate > 120 beats per minute. |
|
European |
| 1,967 |
20,298 |
FINRISK
| Heart failure definition |
| Individuals with a diagnosis corresponding to heart failure in the nationwide hospital discharge or cause of death registers (ICD-10: I50, I110, I130 and I132; ICD-9: 4029B, 404, 4148, 428; ICD-7: 42700, 42710, 428) or special drug reimbursement for heart failure medications (requires a medical certificate that meets predefined criteria for heart failure). |
|
European |
| 364 |
1,864 |
GoDARTS (Affymetrix)
| Heart failure definition |
| HF cases were defined by the presence of at least one of the following criteria: 1. Echocardiographic evidence of left ventricular systolic impairment and diuretic prescription 2. Admission to hospital with HF and receipt of a loop diuretic prescription Patients who were never prescribed a loop diuretic were not classified as HF cases. Date of HF diagnosis was taken as either the date of the earliest echocardiogram or the date of the earliest admission to hospital for HF. |
|
European |
| 204 |
1,947 |
GoDARTS (Illumina)
| Heart failure definition |
| HF cases were defined by the presence of at least one of the following criteria: 1. Echocardiographic evidence of left ventricular systolic impairment and diuretic prescription 2. Admission to hospital with HF and receipt of a loop diuretic prescription Patients who were never prescribed a loop diuretic were not classified as HF cases. Date of HF diagnosis was taken as either the date of the earliest echocardiogram or the date of the earliest admission to hospital for HF. |
|
European |
| 1,060 |
7,709 |
GRADE
| Heart failure definition |
| Inclusion criteria were: patients who were ≥ 18 years of age with a diagnosis of at least moderate systolic left ventricular dysfunction (EF ≤ 30%), and who had an ICD at the University of Pittsburgh Medical Center, Emory University Medical Center, Massachusetts General Hospital, Ohio State University Medical Center, Mid-Ohio Cardiology or the Pittsburgh Veterans Affairs Medical Center. Subjects were excluded if they had intractable Class IV heart failure, and conditions (other than HF) that were expected to limit survival to less than 6 months. |
|
European |
| 1,007 |
2,054 |
LURIC
|
European |
| 755 |
7,590 |
MDCS
|
European |
| 2,206 |
4,523 |
PHFS
|
European |
| 116 |
833 |
PIVUS
|
European |
| 163 |
3,486 |
PREVEND
|
European |
| 211 |
5,033 |
PROSPER
|
European |
| 876 |
3,807 |
Rotterdam 1
|
European |
| 352 |
1,126 |
SHIP
|
European |
| 186 |
9,172 |
SOLID
|
European |
| 604 |
5,176 |
TwinGene
|
European |
| 6,504 |
387,652 |
UK Biobank
|
European |
| 288 |
891 |
ULSAM
|
European |
| 479 |
22,791 |
WGHS
|
European |
