Publications
Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes.
Jiang G, et al.
Kidney Int. 2019 Jan;95(1):178-187.
PMID:30415941
Dataset phenotypes
- BMI
- End-stage renal disease in type 2 diabetes
- Fasting insulin
- Chronic kidney disease in type 2 diabetes
- Coronary artery disease in type 2 diabetes
- Coronary heart disease or stroke or peripheral vascular disease in type 2 diabetes
- eGFR-creat (serum creatinine)
- HDL cholesterol
- Height
- HOMA-B
- Insulinogenic index
- LDL cholesterol
- Microalbuminuria
- Macroalbuminuria vs. controls
- Total cholesterol
- Triglycerides
- Type 2 diabetes
- Urinary albumin-to-creatinine ratio
- Waist circumference
Dataset subjects
| Cases | Controls | Cohort(Click to view selection criteria for cases and controls) | Ancestry |
|---|---|---|---|
| 6,209 | 533 | Hong Kong Diabetes Register | East Asian |
Experiment summary
This study analyzed genetic associations for the phenotypes listed above in a group of subjects of southern Han Chinese ancestry residing in Hong Kong. Type 2 diabetic patients were recruited from the Hong Kong Diabetes Register (HKDR) which was established as a quality improvement program at the Prince of Wales Hospital at the Chinese University of Hong Kong since 1995. These patients were referred from hospital-based specialty clinics, community clinics, and general practitioners between 1995 and 2007. The Register consecutively enrolled patients with diabetes who were referred to the Diabetes Mellitus and Endocrine Centre for comprehensive assessment of diabetic complications and metabolic control. T2D-free control group subjects were either selected randomly from a territory-wide health awareness and promotion program or were recruited from the community for pharmacogenetics studies in hypertension and dyslipidaemia. Whole genome genotyping of samples was supported by the Research Grants Council Theme-based Research Scheme in 2014-2018.