PR interval 1000G GWAS

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Publications

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction.
Ntalla I, Weng L-C, et al.

Nat Commun. 2020 May 21;11(1):2542. doi: 10.1038/s41467-020-15706-x.
PMID:32439900

Phenotypes

  • PR interval

Subjects

Subjects Cohort Ancestry
2216 Age, Gene/Environment Susceptibility Study (AGES) European
1505 The Amish Complex Disease Research Program (AMISH) European
8038 Atherosclerosis Risk in Communities (ARIC) European
2455 Atherosclerosis Risk in Communities (ARIC) African American
485 Brazilian Bambui Cohort Study of Ageing (Bambui) Brazilian
320 BioMe BioBank Program (BioME-Omni) European
773 BioMe BioBank Program (BioME-Omni) African American
1137 BioMe BioBank Program (BioME-Omni) Hispanic
1310 British Genetics of Hypertension (BRIGHT) European
3461 Broad AF study (controls) European
2140 Cardiology and Metabolic Patient Cohort (MGH CAMP) European
4205 Cooperative Health Research in South Tyrol (CHRIS) European
2974 Cardiovascular Health Study (CHS) European
644 Cardiovascular Health Study (CHS) African American
293 CROATIA-Korcula European
347 CROATIA-Split European
80085 ODE Electrocardiograph study (DeCODE) European
1979 Erasmus Rucphen Family Study (ERF) European
7834 Framingham Heart Study (FHS) European
1215 The Finnish Cardiovascular Study (Metabochip) (FINCAVAS-MC) European
1666 Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP) European
941 Genetic Regulation of Arterial Pressure of Humans in the Community (GRAPHIC) European
9087 Generation Scotland: Scottish Family Health Study (GS-SFHS) European
4898 Health 2000 (H2000) European
11686 Hispanic Community Health Survey/Study of Latinos (HCHSSOL) Hispanic
326 INGI-Carlantino (INGI-CARL) European
981 GI - Friuli Venezia Giulia (INGI-FVG) European
2683 Jackson Heart Study (JHS) African American
2724 Kooperative Gesundheitsforschung in der Region Augsburg (KORAF3) European
3457 Kooperative Gesundheitsforschung in der Region Augsburg (KORAS4) European
12823 LifeLines Cohort Study & Biobank (Lifelines) European
2620 Multi-Ethnic Study of Atherosclerosis (MESA) European
1618 Multi-Ethnic Study of Atherosclerosis (MESA) African American
763 Multi-Ethnic Study of Atherosclerosis (MESA) East Asian
602 Microisolates in South Tyrol Study (MICROS) European
5423 Netherlands Epidemiology of Obesity (NEO) European
1785 The Orkney Complex Disease Study (ORCADES) European
834 Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) European
3377 Prevention of REnal and Vascular ENd-stage Disease (PREVEND) European
4227 The PROspective Study of Pravastatin in the Elderly at Risk for vascular disease (PROSPER) European
4587 Rotterdam Study cohort 1 (RS1) European
1897 Rotterdam Study cohort 2 (RS2) European
2873 Rotterdam Study cohort 3 (RS3) European
5799 SardiNIA (SardiNIA) European
2699 Study of Health in Pomerania (SHIP-0) European
941 Study of Health in Pomerania - Trend (SHIP-T) European
3085 TwinsUK (TwinsUK) European
60543 UK Biobank (UK Biobank) European
594 ppsala Longitudinal Study of Adult Men (ULSAM) European
3596 Women's Health Initiative (WHI-GARNET) European
750 Women's Health Initiative (WHI-GECCO) European
821 Women's Health Initiative (WHI-HIPFX) European
986 Women's Health Initiative (WHI-LLS) European
2011 Women's Health Initiative (WHI-MOPMAP) European
2011 Women's Health Initiative (WHI-WHIMS) European
1725 The Cardiovascular Risk in Young Finns Study (YFS) European

Experiment summary

This study is a meta-analysis of associations with the electrocardiographic PR interval. Results are available for the overall multi-ancestry sample set and for a European ancestry subset.

Dataset ID
GWAS_PRw1000GP