| Cases |
Controls |
Cohort (Click to view selection criteria for cases and controls) |
Ancestry |
| 444 |
438 |
Population based ALS registry, The Netherlands (NL1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Cases with a family history for ALS were excluded
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity
|
|
European |
| 305 |
331 |
University Hospital Gasthuisberg Leuven, Belgium (BE1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Cases with a family history for ALS were excluded
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity
|
|
European |
| 582 |
615 |
Population based ALS registry, The Netherlands (NL2)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Cases with a family history for ALS were excluded
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity
|
|
European |
| 483 |
489 |
Umeå University ALS clinic, Sweden (SW1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Cases with a family history for ALS were excluded
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity
|
|
European |
| 0 |
5,951 |
Rotterdam Study, Erasmus University Medical Centre Rotterdam, The Netherlands (NL3)
| Case selection criteria |
Control selection criteria |
|
|
- Healthy controls were participants in the Rotterdam Elderly study, a prospective population based study among elderly living in Ommoord, Rotterdam
- All healthy controls were 55 years or older
|
|
European |
| 232 |
663 |
Hôpitaux de Paris, Hôpital de la Salpêtrière Paris, France (FR1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria
- Cases with a positive family history for ALS were excluded
|
- Controls were healthy individuals ascertained in France
|
|
European |
| 174 |
165 |
Institute of Psychiatry, King’s College London, UK (UK1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria
- Cases with a positive family history for ALS were excluded
|
- Control samples were collected from neurologically normal, unrelated individuals, either spouses of ALS patients, carers or blood donors from the same geographical region
|
|
European |
| 660 |
726 |
Massachusetts General Hospital Boston and Emory University Hospital Atlanta, USA (US1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria
- Cases with a positive family history for ALS were excluded
|
- Control samples were healthy volunteers from Boston or spouses of ALS patients
- Additional healthy control samples were purchased from the Coriell Institute for Medical Research
|
|
European |
| 217 |
211 |
Population based ALS registry, Ireland (IR1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases at Beaumont Hospital in Dublin
- Patients were referred from all regions in Ireland and were part of an ongoing population-based prospective ALS registry
- Original ascertainment criteria excluded patients with a self-reported family history of ALS; post-hoc detailed family history review revealed that 4.07% of patients in fact had a family history of ALS, defined as a first, second or third degree relative with ALS or FTD
|
- Control samples were healthy individuals matched for gender and age; they were either spouses or those accompanying patients to the ALS clinic
|
|
European |
| 103 |
126 |
Population based ALS registry, Ireland (IR2)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria by neurologists specialized in motor neuron diseases at Beaumont Hospital in Dublin
- Patients were referred from all regions in Ireland and were part of an ongoing population-based prospective ALS registry
- 19.44% of ALS patients in the cohort had a family history of ALS, defined as a first, second or third degree relative with ALS or FTD
|
- Control samples were healthy individuals matched for gender and age; they were either spouses or those accompanying patients to the ALS clinic
|
|
European |
| 647 |
0 |
UK Biobank for Motor Neuron Disease Research, UK (UK2)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with ALS in one of 20 UK hospitals by neurologists specialized in motor neuron diseases
- Patients had no family history for ALS
- All patients participated in the UK National Biobank for Motor Neuron Disease Research
|
|
|
European |
| 0 |
520 |
Coriell Institute for Medical Research, USA (US2)
| Case selection criteria |
Control selection criteria |
|
|
- Controls were healthy individuals obtained from the NINDS Neurogenetics repository at the Coriell Institute for Medical Research
|
|
European |
| 275 |
0 |
Coriell Institute for Medical Research, USA (US3)
| Case selection criteria |
Control selection criteria |
- All cases were diagnosed with probable, probable lab supported or definite ALS according to the revised El-Escorial Criteria
- Patients were diagnosed at different sites throughout the United States of America
- Patients with a family history of ALS were excluded
|
|
|
European |
| 140 |
0 |
Population based registry (PARALS), Italy (IT1)
| Case selection criteria |
Control selection criteria |
- All cases were diagnosed with probable, probable lab supported or definite ALS according to the revised El-Escorial Criteria
- Both patients with and without a positive family history for ALS were included
- Patients were ascertained through a population-based registry in the northwestern Italy (PARALS)
|
|
|
European |
| 259 |
245 |
Coriell Institute for Medical Research (IT2)
| Case selection criteria |
Control selection criteria |
- Cases were obtained from the NINDS Neurogenetics repository at the Coriell Institute for Medical Research
- Cases were diagnosed with probable, probable lab-supported or definite ALS according to the revised El-Escorial Criteria
- Patients had no family history for ALS and were white non-Hispanic individuals
|
|
|
European |
| 0 |
2,500 |
Wellcome Trust Case Control Consortium UK National Blood Service, UK (UK3)
| Case selection criteria |
Control selection criteria |
|
|
- Healthy controls were obtained from the WTCCC National Blood Service control group
- Controls were blood donors from England and North Wales
|
|
European |
| 0 |
2,688 |
Wellcome Trust Case Control Consortium 1958 Birth Cohort, United Kingdom (UK4)
| Case selection criteria |
Control selection criteria |
|
|
- Control individuals are part of a population-based cohort that included individuals born in a single week in 1958 in England, Scotland and Wales
|
|
European |
| 0 |
862 |
Coriell Institute for Medical Research, USA (US4)
| Case selection criteria |
Control selection criteria |
|
|
- Controls were elderly obtained from the NINDS Neurogenetics repository at the Coriell Institute for Medical Research
|
|
European |
| 0 |
1985 |
The NeuroGenetics Research Consortium (NGRC), USA (US5)
| Case selection criteria |
Control selection criteria |
| |
- Controls were volunteers or spouses of individuals with Parkinson’s disease
- All individuals were healthy and free of neurodegenerative diseases
|
|
European |
| 0 |
195 |
Population-based cohort, Finland (FIN1)
| Case selection criteria |
Control selection criteria |
|
|
- Controls were obtained from a population-based study of the elderly in Finland
- All individuals were Finnish citizens and not demented at the age of 85 years
|
|
European |
| 393 |
185 |
Helsinki University Central Hospital, Finland (FIN2)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with ALS according to the 1994 El-Escorial criteria by a neurologist specialized in motor neuron diseases
- Both patients with and without a family history for ALS were included
|
|
|
European |
| 0 |
97 |
Population-based cohort, Finland (FIN3)
| Case selection criteria |
Control selection criteria |
|
|
- Controls were obtained from a population-based study of the elderly in Finland
- All individuals were Finnish citizens and not demented at the age of 85 years
|
|
European |
| 1,792 |
1,107 |
Italian Consortium for the Genetics of ALS (SLAGEN), Italy (IT3)
| Case selection criteria |
Control selection criteria |
- All cases were diagnosed with probable or definite ALS according to the revised El-Escorial Critera
- Cases had no family history for ALS
|
- Control samples were healthy blood donors collected via the Istituto Auxologico Italiano
|
|
European |
| 0 |
1,030 |
3C study, Population-based French controls, France (FR2)
| Case selection criteria |
Control selection criteria |
|
|
- Controls were part of the Three-City (3C) Study in France, a population-based study in the cities Bordeaux, Dijon and Montpellier on the relation between vascular diseases and dementia in persons aged 65 years and older
- Controls were free of any neurological disease
|
|
European |
| 0 |
655 |
PopGen, Population-based German controls, Germany (GER1)
| Case selection criteria |
Control selection criteria |
|
|
- Population-based controls were ascertained in Northern Germany and were selected form the PopGen biobank
- Controls were free of any neurological disease
|
|
European |
| 1,207 |
2,137 |
Population based ALS registry, The Netherlands (NL4)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Both cases with and without a family history for ALS were included
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity ascertained through a population based study on ALS in the Netherlands
|
|
European |
| 558 |
273 |
Hannover Medical School and University of Wuerzburg, Germany (GER2)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with possible, probable or definite ALS according to the revised El-Escorial criteria
- Both patients with and without a family history for ALS were included
|
- Healthy controls were obtained at the Department of Transfusion Medicine and Immunohematology at the University of Wuerzburg
|
|
European |
| 309 |
96 |
Population based ALS registries (SLALOM and SLAP), Italy (IT4)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with possible, probable or definite ALS according to the revised El-Escorial criteria
- Both patients with and without a family history for ALS (one first degree relative or two second/third degree relatives) were included
|
- Control subjects were healthy individuals free of neuromuscular diseases, matched for age, gender and geographical region (Piemonte registry)
|
|
European |
| 39 |
45 |
University of Lisbon, Portugal (PU1)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with possible, probable or definite ALS according to the revised El- Escorial criteria by neurologists specialized in motor neuron diseases
- Both cases with and without a family history (third degree relatives) were included
|
- Control subjects were spouses or those accompanying patients to the clinic
|
|
European |
| 103 |
63 |
University of Madrid, University of Barcelona, Spain (SP1)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with possible, probable or definite ALS according to the revised El Escorial criteria
- Patients did not have a family history for ALS
|
- Control samples were healthy individuals, free of neuromuscular disease, matched for gender and age
|
|
European |
| 219 |
231 |
Kantonsspital St. Gallen, Switzerland (SWISS1)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Patients had no family history for ALS
|
- Control samples were age-matched healthy blood donors and primary care givers of ALS patients
|
|
European |
| 215 |
245 |
University Hospital Gasthuisberg Leuven, Belgium (BE2)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Both patients with and without a family history for ALS were included
|
- Control individuals were spouses accompanying patients to the University Hospital Gasthuisberg in Leuven Belgium
|
|
European |
| 143 |
0 |
ALS clinics, Finland (via Umeå University, Sweden) (FIN4)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists that were members of clinical ALS teams throughout Finland
- Both patients with and without a family history for ALS were included
|
|
|
European |
| 268 |
470 |
Population based ALS registry, Ireland (IR3)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with possible, probable or definite ALS according to the revised El- Escorial Criteria by neurologists specialized in motor neuron diseases at Beaumont Hospital in Dublin
- 12.92% of ALS patients in the cohort had a family history of ALS, defined as a first, second or third degree relative with ALS or FTD
|
- Control samples were healthy individuals matched for gender and age
|
|
European |
| 279 |
269 |
ALS clinics, via Umeå University, Sweden (SW2)
| Case selection criteria |
Control selection criteria |
- Patients were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists that were members of clinical ALS teams throughout Sweden
- Both cases with and without a family history for ALS were included
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity
|
|
European |
| 63 |
42 |
University of California Los Angeles, United States of America (US6)
| Case selection criteria |
Control selection criteria |
- Patients fulfilled the El-Escorial Criteria for definite or probable ALS
- Patients had no family history for ALS or FTD
|
- Control participants were population-based individuals
|
|
European |
| 1,486 |
0 |
University of Ulm, Germany (GER3)
| Case selection criteria |
Control selection criteria |
- All patients were diagnosed according to the EFNS Consensus criteria
- Patients with and without a family history of ALS were included
|
|
|
European |
| 360 |
0 |
Paris and Tours, France (FR3)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron diseases at the ALS National Reference Center of Pitié-Salpêtrière Hospital (Paris)
- Additional cases were diagnosed with probable or definite ALS according to the 1994 El-Escorial Criteria1 by neurologists specialized in motor neuron diseases in the ALS Center of the Regional Hospital of Tours
- Both patients with and without a family history for ALS were included
|
|
|
European |
| 550 |
0 |
Massachusetts General Hospital, Boston, Emory University, Atlanta and the Penn ALS Center, University of Pennsylvania, USA (US7)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron disease
- Both patients with and without a family history for ALS were included
|
|
|
European |
| 1,194 |
13 |
UK Biobank for Motor Neuron Disease Research, UK (UK5)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with ALS in one of 20 UK hospitals by neurologists specialized in motor neuron diseases
- Patients had no family history for ALS
|
|
|
European |
| 679 |
615 |
Population based ALS registry, The Netherlands (NL5)
| Case selection criteria |
Control selection criteria |
- Cases were diagnosed with probable or definite ALS according to the revised El-Escorial Criteria by neurologists specialized in motor neuron diseases
- Both cases with and without a family history for ALS were included
|
- Control individuals were free of any neuromuscular disease and matched for age, gender and ethnicity ascertained through a population based study on ALS in the Netherlands
|
|
European |
