Publication
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome.
Park S, Kim S, Kim B, et al.
Nature Genetics. 2024 Nov;56(11):2380-2391. doi: 10.1038/s41588-024-01933-1.
PMID: 39349817
Phenotypes
- Metabolic syndrome (latent liability across BMI, waist circumference, fasting glucose, HDL cholesterol, triglycerides, hypertension, and type 2 diabetes)
Experiment summary
This study conducted a large multivariate GWAS (Genomic SEM) of metabolic syndrome on 10684 cases and 51630 controls of East Asian ancestry, identifying associated loci with enrichment in brain tissues. The authors integrated transcriptomic data to prioritize genes, evaluated polygenic risk, and used PRS-PheWAS and Mendelian randomization to examine associations beyond cardiometabolic disease.
Dataset ID
Park2024_MetS_EA