Publication
Genomics yields biological and phenotypic insights into bipolar disorder.
O'Connell KS, Koromina M, van der Veen T, et al.
Nature. 2025 Mar;639(8056):968-975. doi: 10.1038/s41586-024-08468-9.
PMID: 39843750
Phenotypes
- Bipolar disorder (BD)
- Bipolar I and Bipolar II subtypes
Experiment summary
This African American GWAS meta-analysis combined data from 3150 individuals with bipolar disorder and 7873 controls, identifying genome-wide significant loci. Fine-mapping and variant-to-gene approaches prioritized credible genes, with enrichment in neuronal cell types (e.g., GABAergic interneurons and medium spiny neurons), providing biological and phenotypic insights into bipolar disorder.
Dataset ID
OConnell2024_BIP_AA