Publications
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.
Weng LC, et al.
Sci Rep. 2017 Sep 12;7(1):11303. doi: 10.1038/s41598-017-09396-7
Dataset phenotypes
- AF-SNP age interaction
- AF-over age 65
- AF-age 65 and under
- AF-SNP BMI interaction
- AF-SNP hypertension interaction
- AF-SNP sex interaction
Dataset subjects
| Cases | Controls | Cohort | Ancestry |
|---|---|---|---|
| 448 | 438 | Arrhythmia-Biobank-LMU (AFLMU, formerly known as AFNET) and the Cooperative Health Research in the Region of Augsburg (AFNET/KORA) | European |
| 399 | 5,278 | Age, Gene/Environment Susceptibility Study (AGES) Reykjavik study | European |
| 799 | 8,254 | Atherosclerosis Risk in Communities Study (ARIC) | European |
| 120 | 3,670 | Vanderbilt University Medical Center BioVU Biorepository 660 | European |
| 238 | 4,528 | Vanderbilt University Medical Center BioVU Biorepository o1 | European |
| 807 | 1,854 | Cleveland Clinic Lone Atrial Fibrillation GeneBank Study (CCAF) | European |
| 763 | 2,422 | Cardiovascular Health Study (CHS) | European |
| 559 | 7,867 | Framingham Heart Study (FHS) | European |
| 361 | 2,598 | Ludwigshafen Risk and Cardiovascular Health (LURIC) | European |
| 155 | 2,371 | Multi-Ethnic Study of Atherosclerosis (MESA) | European |
| 366 | 911 | Massachusetts General Hospital/MIGEN (MGH/MIGEN) | European |
| 113 | 3,407 | Prevention of Renal and Vascular Endstage Disease (PREVEND) | European |
| 505 | 4,739 | PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) | European |
| 900 | 10,739 | Rotterdam Study (RS) | European |
| 107 | 1,816 | Study of Health in Pomerania (SHIP) | European |
| 648 | 20,194 | Women’s Genome Health Study (WGHS) | European |
| Total: | 7,288 cases | 81,086 controls | ||
Project
Atrial Fibrillation Consortium
The Atrial Fibrillation Consortium (AFGen) seeks to identify the genetic basis of atrial fibrillation using a wide variety of genetic analyses.
Experiment summary
AFGen GEI GWAS is a genome-wide association study for atrial fibrillation associations in about 88,000 individuals, over 7,000 with AF. The authors further performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index (see the Weng et al. publication cited above).
Dataset ID
GWAS_GEI