Dataset
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Publications
Association between titin loss-of-function variants and early-onset atrial fibrillation.
Choi SH, et al.
JAMA. 2018;320(22):2354-2364. doi:10.1001/jama.2018.18179
Dataset phenotypes
Dataset subjects
| Cases |
Controls |
Cohort |
Ancestry |
| 80 |
0 |
Atherosclerosis Risk in Communities (ARIC)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 61 years of age
- individuals without prior history of MI or heart failure
|
|
|
European |
| 355 |
0 |
Cleveland Clinic Lone Atrial Fibrillation GeneBank Study (CCAF)
| Case selection criteria |
Control selection criteria |
- AF onset between 18 and 61 years of age
- absence of preexisting heart failure, MI, or overt structural heart disease
|
|
|
European |
| 75 |
0 |
Heart and Vascular Health Study (HVH)
| Case selection criteria |
Control selection criteria |
- AF onset between 30 and 61 years of age
- individuals without prior myocardial infarction, valvular heart disease, or heart failure
- includes both AF and atrial flutter
|
|
|
European |
| 108 |
3,477 |
Framingham Heart Study (FHS)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 61 years of age
- absence of preexisting MI or heart failure
|
|
|
European |
| 767 |
0 |
Massachusetts General Hospital atrial fibrillation Study (MGH)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 66 years of age
- absence of preexisting hyperthyroidism, heart failure, MI, or overt structural heart disease
|
|
|
European |
| 120 |
0 |
Partners HealthCare Biobank (Partners)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 61 years of age
- absence of cardiac surgery, cardiomyopathy, MI, or valvular heart disease
|
|
|
European |
| 115 |
0 |
Women’s Genome Health Study (WHGS)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 61 years of age
- no prior history of MI, CHF, or structural heart disease at the time of AF onset
|
|
|
European |
| 1,045 |
0 |
Vanderbilt Atrial Fibrillation Registry (VAFR)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 66 years of age
- absence of heart failure, MI, or overt structural heart disease
|
|
|
European |
| 116 |
0 |
Vanderbilt Atrial Fibrillation Ablation Registry (VAFAR)
| Case selection criteria |
Control selection criteria |
- AF onset prior to 66 years of age
- absence of heart failure, MI, or overt structural heart disease
|
|
|
European |
| 0 |
991 |
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study (COPDGene)
| Case selection criteria |
Control selection criteria |
|
|
|
|
European |
| 0 |
484 |
Cleveland Family Study (CFS)
| Case selection criteria |
Control selection criteria |
|
|
|
|
European |
| 0 |
7 |
Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma Study (GALA II+SAGE)
| Case selection criteria |
Control selection criteria |
|
|
|
|
European |
Experiment summary
In the Early-onset AF TOPMed WGS study, deep-coverage whole-genome sequencing was performed for 2,781 patients who experienced the onset of atrial fibrillation prior to age 66 and for 4,959 control patients, all of European ancestry. The association of variants with AF was analyzed.
