Integrated Classifier T2D predicted effector genes
Integrated Classifier T2D predicted effector genes
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Reference:
Majarian T, Manning A, 2020. Unpublished results.
PMID:nnnIntegrated Classifier Predictions
The integrated classifier predicts which genes are likely relevant to T2D risk within T2D GWAS loci through functional and semantic data.
Starting with genetic credible sets, genetic variants were mapped to genes and annotated by various functional predictors like ChIP-seq, ATAC-seq, and transcription factor binding sites.
Clustering method - Udler 2018
The bNMF soft clustering approach categorizes genetic loci into groups representing likely disease mechanistic pathways.
UK10K BMD GWAS
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Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Zheng H-F, et al.
Nature. 2015 Oct 1;526(7571):112-7. doi: 10.1038/nature14878.
PMID:26367794
Lean body mass GWAS
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, et al.
Nat Commun. 2017 Jul 19;8(1):80. doi: 10.1038/s41467-017-00031-7.
PMID:28724990
UK Biobank eBMD GWAS
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Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.
Kemp JP, Morris JA, Medina-Gomez Cet al.
Nat Genet. 2017 Oct; 49(10): 1468–1475. doi: 10.1038/ng.3949
PMID:28869591
Pediatric musculoskeletal traits GWAS
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Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.
Medina-Gomez C, et al.
Nat Commun. 2017; 8: 121.doi: 10.1038/s41467-017-00108-3
PMID:28743860
Life-course total body BMD GWAS
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Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Medina-Gomez C, et al.
Am J Hum Genet. 2018 Jan 4; 102(1): 88–102. doi: 10.1016/j.ajhg.2017.12.005
PMID:29304378
University of Exeter UACR GWAS
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A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio.
Casanova F, et al.
Hum Mol Genet. 2019 Dec 15;28(24):4197-4207. doi: 10.1093/hmg/ddz243.
PMID:31630189