Dataset

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Publications

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Kilpeläinen TO, et al.
Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494

Dataset

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Publications

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Chambers JC, et al.
Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.

Summary statistics are available for download from the GWAS Catalog.

Publications

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Wood AR, et al.

Diabetes. 2017 Aug;66(8):2296-2309. doi: 10.2337/db16-1452

Dataset

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Publications

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
den Hoed M, et al.
Nat Genet. 2013 Jun;45(6):621-31. doi: 10.1038/ng.2610

Dataset phenotypes

• heart rate

Dataset subjects

Dataset

Download URL: https://www.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files

Note that BMI associations were downloaded from GIANT after the most recent update on June 25, 2018.

Dataset

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Publications

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Köttgen A, et al.
Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500

Download summary statistics at the GIANT Consortium website.

Publications

New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, et al.
Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132

Summary statistics are available for download from the GIANT Consortium website.

Publications

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Graff M, et al.
PLoS Genet. 2017 Apr 27;13(4):e1006528. doi: 10.1371/journal.pgen.1006528

Download summary statistics at the GIANT Consortium website

Publications

FTO genotype is associated with phenotypic variability of body mass index.
Yang J, et al.
Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401

Publications

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.
Chennamsetty I, et al.
Cell Rep. 2016 Oct 4;17(2):527-540. doi: 10.1016/j.celrep.2016.09.005

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Knowles JW, et al.
J Clin Invest. 2015 Apr;125(4):1739-51. doi: 10.1172/JCI74692